Evaluating the Risk to Ostomy Patients Working With Uranium Using the ICRP Biokinetic Model for the Gastrointestinal Tract

نویسندگان

  • Sara Taylor
  • Kathryn Hausbeck
  • Francis A. Cucinotta
چکیده

....................................................................................................................................................... iii List of Tables ................................................................................................................................................ vi List of Figures ................................................................................................................................................ x Key Terms .................................................................................................................................................... xii 1.0 Introduction ............................................................................................................................................ 1 2.0 Background ............................................................................................................................................. 3 2.1 Internal Dosimetry .............................................................................................................................. 3 2.2 Dosimetry Principles ........................................................................................................................... 3 2.3 Annual Limit on Intake ........................................................................................................................ 5 2.4 Skin Dose Calculation .......................................................................................................................... 6 2.5 ICRP Publication 30 Dosimetric Model for the Gastrointestinal Tract................................................ 6 2.6 ICRP 100 Human Alimentary Tract Model .......................................................................................... 8 2.6.1. Transit Times ............................................................................................................................. 11 2.6.2 Absorbed Fraction ...................................................................................................................... 12 2.6.3 Absorption, Retention, and Secretion of Radionuclides ............................................................ 12 2.6.4 Details of the Colon .................................................................................................................... 13 2.7 ICRP 30 Metabolic Data for Uranium ................................................................................................ 14 2.8 ICRP 69 Uranium Systemic Model ..................................................................................................... 15 2.9 Gastrointestinal Procedures ............................................................................................................. 18 2.9.1 Colostomy .................................................................................................................................. 19 2.9.2 Descending and Sigmoid Colostomies ....................................................................................... 21 2.2.3 Transverse Colostomy ................................................................................................................ 21 2.2.4 Ascending Colostomy ................................................................................................................. 22 2.3 Ileostomy .......................................................................................................................................... 22 3.0 Model Development ............................................................................................................................. 24 3.1 MATLAB Simulink .............................................................................................................................. 24 3.2 MATLAB Simulink Modeling .............................................................................................................. 24 3.3 Development of Baseline Model....................................................................................................... 31 3.4 Benchmarking the Baseline Model ................................................................................................... 32

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تاریخ انتشار 2017